Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium

Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium

AIMS Orthostatic hypotension (OH), an independent predictor of mortality and cardiovascular events, strongly correlates with hypertension. Recent genome-wide studies have identified new loci influencing blood pressure (BP) in populations, but their impact on OH remains unknown. METHODS AND RESULTS A total of 38 970 men and women of European ancestry from five population-based cohorts were inc...

Blood pressure during supine exercise in idiopathic orthostatic hypotension.

IDIOPATHIC orthostatie hypotension is characterized by an excessive fall in arterial blood pressure on standing and by other manifestations of an extensive loss of autonomic nervous function. In the present study the arterial blood pressure was measured in seven patients with orthostatic hypotension during the performance of mild leg exercise in the supine position. The finding of a pronounced ...

Noradrenaline release and metabolism in orthostatic (postural) hypotension.

Orthostatic hypotension associated with paroxysmal ventricular tachycardia.

Two patients (aged 46 and 49 years) are presented who gave a history of several years' duration of unsteadiness, dizziness, and syncopal attacks on standing. Both had orthostatic hypotension which was associated with the development of a unifocal paroxysmal ventricular tachycardia. There was no evidence of organic heart disease. In one of the patients the symptoms usually developed when standin...

Comparison of the Assessment of Orthostatic Hypotension Using Peripheral and Central Blood Pressure Measurements

Background Orthostatic hypotension (OH) is associated with falls and cardiovascular events. There is growing evidence that central blood pressure (CBP) is better than peripheral blood pressure (PBP) in predicting adverse outcomes. The objectives of this study were to assess 1) the prevalence of OH identified using PBP and CBP and the levels of agreement, 2) the respective associations between O...